Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice.

Détails

ID Serval
serval:BIB_041E90DB544F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice.
Périodique
Ultrastructural Pathology
Auteur(s)
Finzi G., Davalli A., Placidi C., Usellini L., La Rosa S., Folli F., Capella C.
ISSN
0191-3123 (Print)
ISSN-L
0191-3123
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
29
Numéro
6
Pages
525-533
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Islet transplantation is a new therapeutic approach to type 1 diabetes mellitus. However, in several patients insulin levels are not restored and the glycemic control is inadequate. To clarify the cause of graft failure, the authors investigated with light and electron microscopy some human islet grafts before and after transplantation under the kidney capsule of streptozotocin-induced diabetic nude mice. In isolated islets, both pre- and post-transplantation, the endocrine component was scarcely represented, the beta/alpha cell ratio was reduced, and beta cells showed degenerative aspects such as apoptosis, immature secretory granules, and amylin fibrils deposition. The authors conclude that islet graft failure may be due to an insufficient beta cell mass related to their distress probably caused by anoxia and/or overstimulation.
Mots-clé
Animals, Diabetes Mellitus, Experimental/surgery, Graft Rejection/pathology, Humans, Islets of Langerhans/ultrastructure, Islets of Langerhans Transplantation, Mice, Mice, Nude, Microscopy, Electron, Transmission
Pubmed
Web of science
Création de la notice
06/09/2016 14:48
Dernière modification de la notice
20/08/2019 12:25
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