Validation of an analytical method for nitrous oxide (N2O) laughing gas by headspace gas chromatography coupled to mass spectrometry (HS-GC-MS): Forensic application to a lethal intoxication.

Détails

ID Serval
serval:BIB_03F71641295D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Validation of an analytical method for nitrous oxide (N2O) laughing gas by headspace gas chromatography coupled to mass spectrometry (HS-GC-MS): Forensic application to a lethal intoxication.
Périodique
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Auteur(s)
Giuliani N., Beyer J., Augsburger M., Varlet V.
ISSN
1873-376X (Electronic)
ISSN-L
1570-0232
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
983-984
Pages
90-93
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Drug abuse is a widespread problem affecting both teenagers and adults. Nitrous oxide is becoming increasingly popular as an inhalation drug, causing harmful neurological and hematological effects. Some gas chromatography-mass spectrometry (GC-MS) methods for nitrous oxide measurement have been previously described. The main drawbacks of these methods include a lack of sensitivity for forensic applications; including an inability to quantitatively determine the concentration of gas present. The following study provides a validated method using HS-GC-MS which incorporates hydrogen sulfide as a suitable internal standard allowing the quantification of nitrous oxide. Upon analysis, sample and internal standard have similar retention times and are eluted quickly from the molecular sieve 5Å PLOT capillary column and the Porabond Q column therefore providing rapid data collection whilst preserving well defined peaks. After validation, the method has been applied to a real case of N2O intoxication indicating concentrations in a mono-intoxication.
Pubmed
Web of science
Création de la notice
27/01/2015 14:53
Dernière modification de la notice
20/08/2019 12:25
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