Mechanismen der Invasion von Karzinomen der Kopf- und Halsregion [Mechanisms of invasiveness of cancers of the head and neck region].
Details
Serval ID
serval:BIB_03F37127D41D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mechanismen der Invasion von Karzinomen der Kopf- und Halsregion [Mechanisms of invasiveness of cancers of the head and neck region].
Journal
HNO
ISSN
0017-6192 (Print)
ISSN-L
0017-6192
Publication state
Published
Issued date
2001
Volume
49
Number
11
Pages
902-909
Language
german
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
BACKGROUND: Squamous cell carcinomas of the head and neck region are highly aggressive cancers. Survival of these patients critically depends on the prevention of locoregional recurrences. A locoregional relapse is associated with an invasive growth pattern of the primary cancer. Thus, we need to understand regulatory mechanisms of cancer invasion to be able to develop therapeutic strategies, which may help to improve survival in this patient population.
METHOD: Literature search.
RESULTS: Certain tumor proteases are required for invasive growth of head and neck cancers.
DISCUSSION: It is our understanding that further indepth investigation of mechanisms involved in the regulation of protease expression may help to develop treatment strategies, which improve survival by reducing the invasive capacity of head and neck cancer cells.
METHOD: Literature search.
RESULTS: Certain tumor proteases are required for invasive growth of head and neck cancers.
DISCUSSION: It is our understanding that further indepth investigation of mechanisms involved in the regulation of protease expression may help to develop treatment strategies, which improve survival by reducing the invasive capacity of head and neck cancer cells.
Keywords
Carcinoma, Squamous Cell/mortality, Carcinoma, Squamous Cell/pathology, Endopeptidases/physiology, Humans, Lymph Nodes/pathology, Lymphatic Metastasis/pathology, Neoplasm Invasiveness, Neoplasm Recurrence, Local/mortality, Neoplasm Recurrence, Local/pathology, Neoplastic Cells, Circulating, Otorhinolaryngologic Neoplasms/mortality, Otorhinolaryngologic Neoplasms/pathology, Prognosis, Survival Rate
Pubmed
Web of science
Create date
21/01/2013 15:10
Last modification date
20/08/2019 12:25
Usage data
