GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.

Détails

ID Serval
serval:BIB_03E134BDD2A7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Cani P.D., Holst J.J., Drucker D.J., Delzenne N.M., Thorens B., Burcelin R., Knauf C.
ISSN
0303-7207[print], 0303-7207[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
276
Numéro
1-2
Pages
18-23
Langue
anglais
Résumé
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively. The molecular mechanisms responsible for intestinal cell glucose sensing are unknown but could be related to those described for beta-cells, brain and hepatoportal sensors. We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice. GLP-1 secretion was reduced in all mutant mice, while GIP secretion did not require GLUT2. Intestinal GLP-1 content was reduced only in GIP and GLUT2 receptors knockout mice suggesting that this impairment could contribute to the phenotype. Intestinal GIP content was similar in all mice studied. Furthermore, the impaired incretins secretion was associated with a reduced glucose-stimulated insulin secretion and an impaired glucose tolerance in all mice. In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2.
Mots-clé
Animals, Gastric Inhibitory Polypeptide/secretion, Glucagon-Like Peptide 1/secretion, Glucose/pharmacology, Glucose Intolerance, Glucose Tolerance Test, Glucose Transporter Type 2/deficiency, Glucose Transporter Type 2/metabolism, Intestines/drug effects, Intestines/metabolism, Mice, Mice, Knockout, Models, Biological, Portal System/drug effects, Portal System/metabolism, Receptors, Gastrointestinal Hormone/deficiency, Receptors, Gastrointestinal Hormone/metabolism, Receptors, Glucagon/deficiency, Receptors, Glucagon/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 13:41
Dernière modification de la notice
20/08/2019 12:25
Données d'usage