GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.

Details

Serval ID
serval:BIB_03E134BDD2A7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
Journal
Molecular and Cellular Endocrinology
Author(s)
Cani P.D., Holst J.J., Drucker D.J., Delzenne N.M., Thorens B., Burcelin R., Knauf C.
ISSN
0303-7207[print], 0303-7207[linking]
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
276
Number
1-2
Pages
18-23
Language
english
Abstract
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively. The molecular mechanisms responsible for intestinal cell glucose sensing are unknown but could be related to those described for beta-cells, brain and hepatoportal sensors. We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice. GLP-1 secretion was reduced in all mutant mice, while GIP secretion did not require GLUT2. Intestinal GLP-1 content was reduced only in GIP and GLUT2 receptors knockout mice suggesting that this impairment could contribute to the phenotype. Intestinal GIP content was similar in all mice studied. Furthermore, the impaired incretins secretion was associated with a reduced glucose-stimulated insulin secretion and an impaired glucose tolerance in all mice. In conclusion, both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2.
Keywords
Animals, Gastric Inhibitory Polypeptide/secretion, Glucagon-Like Peptide 1/secretion, Glucose/pharmacology, Glucose Intolerance, Glucose Tolerance Test, Glucose Transporter Type 2/deficiency, Glucose Transporter Type 2/metabolism, Intestines/drug effects, Intestines/metabolism, Mice, Mice, Knockout, Models, Biological, Portal System/drug effects, Portal System/metabolism, Receptors, Gastrointestinal Hormone/deficiency, Receptors, Gastrointestinal Hormone/metabolism, Receptors, Glucagon/deficiency, Receptors, Glucagon/metabolism
Pubmed
Web of science
Create date
24/01/2008 13:41
Last modification date
20/08/2019 12:25
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