Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish.

Details

Ressource 1Download: Younes_journal.pone.0245239.pdf (2379.09 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_036879F271AC
Type
Article: article from journal or magazin.
Collection
Publications
Title
Hmx1 regulates urfh1 expression in the craniofacial region in zebrafish.
Journal
PloS one
Author(s)
El Fersioui Y., Pinton G., Allaman-Pillet N., Schorderet D.F.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
16
Number
1
Pages
e0245239
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
H6 family homeobox 1 (HMX1) regulates multiple aspects of craniofacial development as it is widely expressed in the eye, peripheral ganglia and branchial arches. Mutations in HMX1 are linked to an ocular defect termed Oculo-auricular syndrome of Schorderet-Munier-Franceschetti (MIM #612109). We identified UHRF1 as a target of HMX1 during development. UHRF1 and its partner proteins actively regulate chromatin modifications and cellular proliferation. Luciferase assays and in situ hybridization analyses showed that HMX1 exerts a transcriptional inhibitory effect on UHRF1 and a modification of its expression pattern. Overexpression of hmx1 in hsp70-hmx1 zebrafish increased uhrf1 expression in the cranial region, while mutations in the hmx1 dimerization domains reduced uhrf1 expression. Moreover, the expression level of uhrf1 and its partner dnmt1 was increased in the eye field in response to hmx1 overexpression. These results indicate that hmx1 regulates uhrf1 expression and, potentially through regulating the expression of factors involved in DNA methylation, contribute to the development of the craniofacial region of zebrafish.
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2021 15:08
Last modification date
24/02/2022 6:33
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