Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces.

Détails

ID Serval
serval:BIB_034FAA71F9A7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces.
Périodique
Future Microbiology
Auteur(s)
Corthésy B.
ISSN
1746-0921 (Electronic)
ISSN-L
1746-0913
Statut éditorial
Publié
Date de publication
2010
Volume
5
Numéro
5
Pages
817-829
Langue
anglais
Résumé
The contribution of secretory immunoglobulin A (SIgA) antibodies in the defense of mucosal epithelia plays an important role in preventing pathogen adhesion to host cells, therefore blocking dissemination and further infection. This mechanism, referred to as immune exclusion, represents the dominant mode of action of the antibody. However, SIgA antibodies combine multiple facets, which together confer properties extending from intracellular and serosal neutralization of antigens, activation of non-inflammatory pathways and homeostatic control of the endogenous microbiota. The sum of these features suggests that future opportunities for translational application from research-based knowledge to clinics include the mucosal delivery of bioactive antibodies capable of preserving immunoreactivity in the lung, gastrointestinal tract, the genito-urinary tract for the treatment of infections. This article covers topics dealing with the structure of SIgA, the dissection of its mode of action in epithelia lining different mucosal surfaces and its potential in immunotherapy against infectious pathogens.
Mots-clé
Humans, Immunity, Mucosal, Immunoglobulin A, Secretory/chemistry, Immunoglobulin A, Secretory/immunology, Secretory Component/chemistry, Secretory Component/immunology
Pubmed
Web of science
Création de la notice
31/05/2010 15:17
Dernière modification de la notice
03/03/2018 13:20
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