Notch signaling in T- and B-cell development.

Détails

ID Serval
serval:BIB_034C30D7FA31
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Notch signaling in T- and B-cell development.
Périodique
Current opinion in immunology
Auteur(s)
Radtke F., Wilson A., MacDonald H.R.
ISSN
0952-7915
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
16
Numéro
2
Pages
174-179
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor in T-cell lineage commitment. More recent studies have addressed the roles of other Notch receptors and ligands, as well as their downstream targets, revealing additional novel functions of Notch signaling in intra-thymic T-cell development, B-cell development and peripheral T-cell function.
Mots-clé
Animals, B-Lymphocytes/physiology, Cell Lineage, Gene Expression Regulation, Developmental, Membrane Proteins/metabolism, Mice, Mice, Transgenic, Models, Biological, Receptors, Notch, Signal Transduction, T-Lymphocytes/physiology
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 12:25
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