Cracking the BAFF code.

Détails

Ressource 1Télécharger: BIB_0347D39CE7CD.P001.pdf (790.34 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_0347D39CE7CD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cracking the BAFF code.
Périodique
Nature reviews. Immunology
Auteur(s)
Mackay F., Schneider P.
ISSN
1474-1741[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
9
Numéro
7
Pages
491-502
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
The tumour necrosis factor (TNF) family members B cell activating factor (BAFF) and APRIL (a proliferation-inducing ligand) are crucial survival factors for peripheral B cells. An excess of BAFF leads to the development of autoimmune disorders in animal models, and high levels of BAFF have been detected in the serum of patients with various autoimmune conditions. In this Review, we consider the possibility that in mice autoimmunity induced by BAFF is linked to T cell-independent B cell activation rather than to a severe breakdown of B cell tolerance. We also outline the mechanisms of BAFF signalling, the impact of ligand oligomerization on receptor activation and the progress of BAFF-depleting agents in the clinical setting.
Mots-clé
Animals, Autoimmunity/immunology, B-Cell Activating Factor/immunology, B-Cell Activating Factor/metabolism, B-Cell Maturation Antigen/immunology, B-Cell Maturation Antigen/metabolism, B-Lymphocyte Subsets/immunology, B-Lymphocyte Subsets/metabolism, Humans, Immune Tolerance/immunology, Ligands, Lymphocyte Activation/immunology, Signal Transduction/immunology, Toll-Like Receptors/immunology, Toll-Like Receptors/metabolism, Transmembrane Activator and CAML Interactor Protein/immunology, Transmembrane Activator and CAML Interactor Protein/metabolism, Tumor Necrosis Factor Ligand Superfamily Member 13/immunology, Tumor Necrosis Factor Ligand Superfamily Member 13/metabolism, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/immunology, Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism
Pubmed
Web of science
Création de la notice
11/11/2009 13:51
Dernière modification de la notice
03/03/2018 13:20
Données d'usage