Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF

Détails

ID Serval
serval:BIB_032FEFF9117A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF
Périodique
FEBS Letters
Auteur(s)
Albrecht  H., Tschopp  J., Jongeneel  C. V.
ISSN
0014-5793 (Print)
Statut éditorial
Publié
Date de publication
08/1994
Volume
351
Numéro
1
Pages
45-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 29
Résumé
The recent demonstration of the anti-oxidant properties of the Bcl-2 gene product suggested that expression of Bcl-2 may interfere with the nuclear migration of the NF-kappa B transcription factor, which is thought to depend on the presence of reactive oxygen intermediates. In mouse L cells, overexpression of Bcl-2 interfered with the activation of NF-kappa B by H2O2. However, Bcl-2 had no effect on the activation of NF-kappa B by TNF, even though it protected cells from TNF-induced apoptosis. The effects of exogenous pyrrolidine dithiocarbamate were very similar to those of Bcl-2 overexpression. We conclude that the protective effects of anti-oxidants against induced apoptotic cell death are unrelated to their ability to interfere with NF-kappa B activation.
Mots-clé
Animals Antioxidants Apoptosis Base Sequence Cell Line L Cells (Cell Line) Mice Molecular Sequence Data NF-kappa B/*metabolism Oligodeoxyribonucleotides Protein-Tyrosine Kinases/*physiology Proto-Oncogene Proteins/*physiology Proto-Oncogene Proteins c-bcl-2 *Reactive Oxygen Species Tumor Necrosis Factor-alpha/*physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:39
Dernière modification de la notice
08/05/2019 13:47
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