Diagnostic Performance and Prognostic Value of PET/CT with Different Tracers for Brain Tumors: A Systematic Review of Published Meta-Analyses.
Details
Serval ID
serval:BIB_032191122087
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostic Performance and Prognostic Value of PET/CT with Different Tracers for Brain Tumors: A Systematic Review of Published Meta-Analyses.
Journal
International journal of molecular sciences
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
20/09/2019
Peer-reviewed
Oui
Volume
20
Number
19
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Systematic Review
Publication Status: epublish
Publication Status: epublish
Abstract
Several meta-analyses reporting data on the diagnostic performance or prognostic value of positron emission tomography (PET) with different tracers in detecting brain tumors have been published so far. This review article was written to summarize the evidence-based data in these settings.
We have performed a comprehensive literature search of meta-analyses published in the Cochrane library and PubMed/Medline databases (from inception through July 2019) about the diagnostic performance or prognostic value of PET with different tracers in patients with brain tumors.
We have summarized the results of 24 retrieved meta-analyses on the use of PET or PET/computed tomography (CT) with different tracers in brain tumors. The tracers included were: fluorine-18 fluorodeoxyglucose ( <sup>18</sup> F-FDG), carbon-11 methionine ( <sup>11</sup> C-methionine), fluorine-18 fluoroethyltyrosine ( <sup>18</sup> F-FET), fluorine-18 dihydroxyphenylalanine ( <sup>18</sup> F-FDOPA), fluorine-18 fluorothymidine ( <sup>18</sup> F-FLT), and carbon-11 choline ( <sup>11</sup> C-choline). Evidence-based data demonstrated good diagnostic performance of PET with different tracers in detecting brain tumors, in particular, radiolabelled amino acid tracers showed the highest diagnostic performance values. All the PET tracers evaluated had significant prognostic value in patients with glioma.
Evidence-based data showed a good diagnostic performance for some PET tracers in specific indications and significant prognostic value in brain tumors.
We have performed a comprehensive literature search of meta-analyses published in the Cochrane library and PubMed/Medline databases (from inception through July 2019) about the diagnostic performance or prognostic value of PET with different tracers in patients with brain tumors.
We have summarized the results of 24 retrieved meta-analyses on the use of PET or PET/computed tomography (CT) with different tracers in brain tumors. The tracers included were: fluorine-18 fluorodeoxyglucose ( <sup>18</sup> F-FDG), carbon-11 methionine ( <sup>11</sup> C-methionine), fluorine-18 fluoroethyltyrosine ( <sup>18</sup> F-FET), fluorine-18 dihydroxyphenylalanine ( <sup>18</sup> F-FDOPA), fluorine-18 fluorothymidine ( <sup>18</sup> F-FLT), and carbon-11 choline ( <sup>11</sup> C-choline). Evidence-based data demonstrated good diagnostic performance of PET with different tracers in detecting brain tumors, in particular, radiolabelled amino acid tracers showed the highest diagnostic performance values. All the PET tracers evaluated had significant prognostic value in patients with glioma.
Evidence-based data showed a good diagnostic performance for some PET tracers in specific indications and significant prognostic value in brain tumors.
Keywords
Brain Neoplasms/diagnostic imaging, Humans, Positron Emission Tomography Computed Tomography, Prognosis, Radioactive Tracers, Radiopharmaceuticals/therapeutic use, PET, brain metastases, brain tumors, diagnostic performance, glioma, meta-analysis, positron emission tomography, prognosis
Pubmed
Web of science
Open Access
Yes
Create date
27/09/2019 9:13
Last modification date
15/01/2021 8:08
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