Cancer: Linking Powerhouses to Suicidal Bags.

Détails

Ressource 1Télécharger: 28932704_BIB_030409EABA61.pdf (864.35 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_030409EABA61
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cancer: Linking Powerhouses to Suicidal Bags.
Périodique
Frontiers in Oncology
Auteur(s)
Martinez-Carreres L., Nasrallah A., Fajas L.
ISSN
2234-943X (Print)
ISSN-L
2234-943X
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
7
Pages
204
Langue
anglais
Résumé
Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense. Many of these interactions are well established, but little is known about the interplay between mitochondria and lysosomes, and their deregulation in cancer. The present review focuses on the common signaling pathways of both organelles, as well as the processes in which they both physically interact, their changes under pathological conditions, and the impact on targeting those organelles for treating cancer.

Mots-clé
AMP-activated protein kinase, Rab7, cancer, lysosomal membrane permeabilization, lysosomes, mammalian target of rapamycin, mitochondria, mitophagy
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/10/2017 10:30
Dernière modification de la notice
08/05/2019 13:47
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