β-Arrestin2 influences the response to methadone in opioid-dependent patients.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_02BE3E233F45
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
β-Arrestin2 influences the response to methadone in opioid-dependent patients.
Périodique
Pharmacogenomics Journal
Auteur(s)
Oneda B., Crettol S., Bochud M., Besson J., Croquette-Krokar M., Hämmig R., Monnat M., Preisig M., Eap C.B.
ISSN
1473-1150 (Electronic)
ISSN-L
1470-269X
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
11
Numéro
4
Pages
258-266
Langue
anglais
Résumé
β-Arrestin2 (ARRB2) is a component of the G-protein-coupled receptor complex and is involved in μ-opioid and dopamine D(2) receptor signaling, two central processes in methadone signal transduction. We analyzed 238 patients in methadone maintenance treatment (MMT) and identified a haplotype block (rs34230287, rs3786047, rs1045280 and rs2036657) spanning almost the entire ARRB2 locus. Although none of these single nucleotide polymorphisms (SNPs) leads to a change in amino-acid sequence, we found that for all the SNPs analyzed, with exception of rs34230287, homozygosity for the variant allele confers a nonresponding phenotype (n=73; rs1045280C and rs2036657G: OR=3.1, 95% CI=1.5-6.3, P=0.004; rs3786047A: OR=2.5, 95% CI=1.2-5.1, P=0.02) also illustrated by a 12-fold shorter period of negative urine screening (P=0.01). The ARRB2 genotype may thus contribute to the interindividual variability in the response to MMT and help to predict response to treatment.
Mots-clé
Adolescent, Adult, Aged, Analgesics, Opioid/therapeutic use, Arrestins/genetics, Chi-Square Distribution, Cross-Sectional Studies, Female, Gene Frequency, Genotype, Humans, Individualized Medicine, Logistic Models, Male, Methadone/therapeutic use, Middle Aged, Odds Ratio, Opiate Substitution Treatment, Opioid-Related Disorders/genetics, Opioid-Related Disorders/rehabilitation, Pharmacogenetics, Phenotype, Polymorphism, Single Nucleotide, Retrospective Studies, Switzerland, Time Factors, Treatment Outcome, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/09/2011 19:10
Dernière modification de la notice
09/09/2019 7:08
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