Dilation Modifies Association Between Symptoms and Esophageal Eosinophilia in Adult Patients With Eosinophilic Esophagitis.
Details
Serval ID
serval:BIB_02A40D93DD56
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dilation Modifies Association Between Symptoms and Esophageal Eosinophilia in Adult Patients With Eosinophilic Esophagitis.
Journal
The American journal of gastroenterology
ISSN
1572-0241 (Electronic)
ISSN-L
0002-9270
Publication state
Published
Issued date
12/2020
Peer-reviewed
Oui
Volume
115
Number
12
Pages
2098-2102
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
We investigated whether dilation modifies the association between symptoms and esophageal eosinophilia (peak esophageal eosinophils/high-power field [eos/hpf]) in patients with eosinophilic esophagitis enrolled into a randomized trial comparing the efficacy of budesonide and fluticasone.
Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations.
In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients.
Dilation modifies association between symptoms and eos/hpf (clinicaltrials.gov NCT02019758).
Baseline Dysphagia Symptom Questionnaire and Eosinophilic Esophagitis Activity Index were available in 102 and 73 patients, respectively, of whom 56 and 39 underwent dilation at screening endoscopy before symptom assessment. The pair-wise relationship between Dysphagia Symptom Questionnaire, Eosinophilic Esophagitis Activity Index, and eos/hpf was analyzed with nonparametric correlations.
In nondilated patients, the association between baseline eos/hpf and symptoms was moderate and significant, although it was abolished in dilated patients.
Dilation modifies association between symptoms and eos/hpf (clinicaltrials.gov NCT02019758).
Keywords
Deglutition Disorders/complications, Deglutition Disorders/diagnosis, Deglutition Disorders/therapy, Dilatation/methods, Eosinophilia/complications, Eosinophilia/diagnosis, Eosinophilia/therapy, Eosinophilic Esophagitis/complications, Eosinophilic Esophagitis/diagnosis, Eosinophilic Esophagitis/therapy, Esophagoscopy, Esophagus, Female, Humans, Male, Severity of Illness Index, Symptom Assessment
Pubmed
Web of science
Create date
09/10/2020 13:29
Last modification date
16/04/2024 6:12
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