Validity of the sonographic measurement of the diameters of the ascending aorta in rats.

Details

Serval ID
serval:BIB_027DD1034BC2
Type
Article: article from journal or magazin.
Collection
Publications
Title
Validity of the sonographic measurement of the diameters of the ascending aorta in rats.
Journal
Ultraschall in der Medizin
Author(s)
Radu C.N., Michineau S., Hidalgo A., Blanc R., Gervais M., Loisance D.Y., Allaire E., Kirsch M.
ISSN
1438-8782 (Electronic)
ISSN-L
0172-4614
Publication state
Published
Issued date
02/2010
Peer-reviewed
Oui
Volume
31
Number
1
Pages
26-30
Language
english german
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The objective of this investigation was to compare transthoracic ultrasound (US) determinations of ascending aortic diameters in rats with video microscopy (VM), the current standard for measuring aortic diameters in rats.
The diameter of the ascending aorta was measured in 111 adult Lewis male rats, by VM and US, with a 9 MHz probe, before and after intervention for induction of experimental aneurysm of the ascending aorta.
The Bland-Altman test showed a high degree of agreement between the two methods, with a bias of only 0.23 mm (95 % confidence limits - 0.86 - 0.39 mm). Also, the measurements obtained by US correlated highly (r = 0.83, p < 0.0001) with those obtained by VM. Rat ascending aortic diameters obtained both by VM and US correlated significantly with the weight (r = 0.62 and r = 0.39, respectively), and with the age of the animals (r = 0.74 and r = 0.49, respectively).
This study demonstrates that noninvasive US ascending aortic measurements are a reliable supplement to VM for the development of an ascending aortic aneurysm model, and for monitoring the efficiency of novel therapeutic agents.
Keywords
Animals, Aorta/diagnostic imaging, Aortic Aneurysm, Thoracic/diagnostic imaging, Disease Models, Animal, Image Processing, Computer-Assisted, Male, Microscopy, Video, Rats, Rats, Inbred Lew, Sensitivity and Specificity, Ultrasonography
Pubmed
Web of science
Create date
30/03/2019 17:33
Last modification date
20/08/2019 12:24
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