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Differential effects of two anti-apo-cytochrome c-specific monoclonal antibodies on the function of apo-cytochrome c-specific murine T cell clones.
Journal of Immunology
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A murine monoclonal antibody (SJL 2-4) specific for the antigen apo-cytochrome c was shown to inhibit both antigen-induced proliferation and lymphokine secretion by an apo-cytochrome c-specific BALB/c helper T cell clone. The inhibition was specific because additional apo-cytochrome c-specific T cell clones were not inhibited by the same monoclonal antibody. Time course studies of the inhibition indicated that the initial 8 hr of contact between T cell clones and antigen-presenting cells were critical for activation of the T cell clones. Inhibition of T cell functions by antigen-specific antibodies appeared to correlate with the antibody-antigen binding constant because a second monoclonal antibody (Cyt-1-59), with identical specificity but with a lower affinity constant for apo-cytochrome c, had very little inhibitory effect on the proliferation or lymphokine secretion of apo-cytochrome c-specific T cell clones.
Animals, Antibodies, Monoclonal/physiology, Apoproteins/analysis, Apoproteins/immunology, Binding, Competitive, Cell Differentiation, Clone Cells/cytology, Clone Cells/immunology, Cytochrome c Group/analysis, Cytochrome c Group/immunology, Cytochromes c, Dose-Response Relationship, Immunologic, Epitopes/analysis, Kinetics, Lymphocyte Activation, Lymphokines/biosynthesis, Macrophage-Activating Factors, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, T-Lymphocytes/cytology, T-Lymphocytes/immunology
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