Prévalence du virus d'Epstein-Barr dans le syndrome de Sjögren en Tunisie [Prevalence of Epstein-Barr virus in Sjögren's syndrome in Tunisia]
Details
Serval ID
serval:BIB_0269883A8419
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prévalence du virus d'Epstein-Barr dans le syndrome de Sjögren en Tunisie [Prevalence of Epstein-Barr virus in Sjögren's syndrome in Tunisia]
Journal
La Revue de medecine interne
ISSN
0248-8663 (Print)
ISSN-L
0248-8663
Publication state
Published
Issued date
07/2006
Peer-reviewed
Oui
Volume
27
Number
7
Pages
519-523
Language
french
Notes
Publication types: Comparative Study ; English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The cause of Sjögren's syndrome is unclear. Several studies suggested the role of Epstein-Barr virus (EBV) in the pathogenesis of this syndrome, but this always remains a subject of numerous controversies. The purpose of this study was to evaluate the prevalence of EBV in Sjögren's syndrome in Tunisia.
A series of 31 paraffin-embedded biopsies of salivary glands from patients with Sjögren's syndrome were studied in comparison with 19 control glands. EBV was investigated by PCR, EBERs in situ hybridization and by immunohistochemistry for the detection of LMP1, EBNA2 and ZEBRA.
EBV DNA was detected by PCR in 3 of 22 PCR beta-globin positive Sjögren's syndrome cases (13.6%) and in 2 of 17 PCR beta-globin positive control glands (11.7%); in situ hybridization positivity was noted in rare lymphocytes in the 3 EBV positive cases of Sjögren's syndrome, but not in control glands; immunohistochemical study was negative in all cases.
EBV infection does not appear to play a significant role in the pathogenesis of Sjögren's syndrome in Tunisia.
A series of 31 paraffin-embedded biopsies of salivary glands from patients with Sjögren's syndrome were studied in comparison with 19 control glands. EBV was investigated by PCR, EBERs in situ hybridization and by immunohistochemistry for the detection of LMP1, EBNA2 and ZEBRA.
EBV DNA was detected by PCR in 3 of 22 PCR beta-globin positive Sjögren's syndrome cases (13.6%) and in 2 of 17 PCR beta-globin positive control glands (11.7%); in situ hybridization positivity was noted in rare lymphocytes in the 3 EBV positive cases of Sjögren's syndrome, but not in control glands; immunohistochemical study was negative in all cases.
EBV infection does not appear to play a significant role in the pathogenesis of Sjögren's syndrome in Tunisia.
Keywords
Adult, Capsid/chemistry, DNA, Viral/analysis, DNA-Binding Proteins/analysis, Epstein-Barr Virus Infections/diagnosis, Female, Herpesvirus 4, Human/genetics, Herpesvirus 4, Human/isolation & purification, Humans, Immunohistochemistry, In Situ Hybridization, Male, Middle Aged, Polymerase Chain Reaction, RNA, Viral/analysis, Salivary Glands/virology, Sjogren's Syndrome/virology, Trans-Activators/analysis, Tunisia, Viral Matrix Proteins/analysis, Viral Proteins/analysis, Virus Latency/genetics, Virus Replication/genetics
Pubmed
Web of science
Create date
17/10/2023 9:38
Last modification date
20/10/2023 6:10
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