Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy.

Details

Serval ID
serval:BIB_025704A90C14
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy.
Journal
Critical Reviews In Biotechnology
Author(s)
Zhao A., Tohidkia M.R., Siegel D.L., Coukos G., Omidi Y.
ISSN
1549-7801 (Electronic)
ISSN-L
0738-8551
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
36
Number
2
Pages
276-289
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Phage display technology (PDT), a combinatorial screening approach, provides a molecular diversity tool for creating libraries of peptides/proteins and discovery of new recombinant therapeutics. Expression of proteins such as monoclonal antibodies (mAbs) on the surface of filamentous phage can permit the selection of high affinity and specificity therapeutic mAbs against virtually any target antigen. Using a number of diverse selection platforms (e.g. solid phase, solution phase, whole cell and in vivo biopannings), phage antibody libraries (PALs) from the start point provides great potential for the isolation of functional mAb fragments with diagnostic and/or therapeutic purposes. Given the pivotal role of PDT in the discovery of novel therapeutic/diagnostic mAbs, in the current review, we provide an overview on PALs and discuss their impact in the advancement of engineered mAbs.
Pubmed
Web of science
Create date
03/03/2015 18:22
Last modification date
20/08/2019 12:24
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