Popliteal lymph node response to procainamide and isoniazid. Role of beta-naphthoflavone, phenobarbitone and S9-mix pretreatment.

Details

Serval ID
serval:BIB_01D55A04B710
Type
Article: article from journal or magazin.
Collection
Publications
Title
Popliteal lymph node response to procainamide and isoniazid. Role of beta-naphthoflavone, phenobarbitone and S9-mix pretreatment.
Journal
Toxicology Letters
Author(s)
Patriarca C., Verdier F., Brouland J.P., Descotes J.
ISSN
0378-4274 (Print)
ISSN-L
0378-4274
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
66
Number
1
Pages
21-28
Language
english
Notes
Publication types: Comparative Study ; Journal Article Publication Status: ppublish
Abstract
The popliteal lymph node assay (PLNA) was proposed for the preclinical prediction of xenobiotics-induced autoimmune reactions in humans. Among the substances so far tested in this model, procainamide and isoniazid gave negative PLNA responses despite reports of lupus syndromes in man. To confirm the hypothesis that a metabolite instead of the parent molecule is involved, rats were pretreated with phenobarbital or beta-naphthoflavone, then injected with procainamide or isoniazid. In additional groups of animals, procainamide or isoniazid were injected together with S9-mix following various incubation times. Pretreated rats had a positive PLNA response when injected with procainamide, whereas preincubation with S9-mix resulted in a positive response to isoniazid. These results further support the validity of the PLNA.
Keywords
Animals, Autoimmune Diseases/chemically induced, Benzoflavones/pharmacology, Biotransformation, Drug Evaluation, Preclinical, Enzyme Induction, Female, Isoniazid/pharmacokinetics, Isoniazid/toxicity, Knee, Liver Extracts/pharmacology, Lymph Nodes/drug effects, Male, Models, Biological, Phenobarbital/pharmacology, Procainamide/pharmacokinetics, Procainamide/toxicity, Rats, Rats, Inbred BN, Rats, Sprague-Dawley, Time Factors, beta-Naphthoflavone
Pubmed
Web of science
Create date
13/10/2015 8:57
Last modification date
20/08/2019 12:24
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