PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium.

Détails

Ressource 1Télécharger: ijms-18-02559-v2.pdf (3341.32 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_019B147E2411
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium.
Périodique
International journal of molecular sciences
Auteur(s)
Duszka K., Oresic M., Le May C., König J., Wahli W.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
28/11/2017
Peer-reviewed
Oui
Volume
18
Numéro
12
Pages
E2559
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Nuclear receptor PPARγ affects lipid metabolism in several tissues, but its role in intestinal lipid metabolism has not been explored. As alterations have been observed in the plasma lipid profile of ad libitum fed intestinal epithelium-specific PPARγ knockout mice (iePPARγKO), we submitted these mice to lipid gavage challenges. Within hours after gavage with long chain unsaturated fatty acid (FA)-rich canola oil, the iePPARγKO mice had higher plasma free FA levels and lower gastric inhibitory polypeptide levels than their wild-type (WT) littermates, and altered expression of incretin genes and lipid metabolism-associated genes in the intestinal epithelium. Gavage with the medium chain saturated FA-rich coconut oil did not result in differences between the two genotypes. Furthermore, the iePPARγKO mice did not exhibit defective lipid uptake and stomach emptying; however, their intestinal transit was more rapid than in WT mice. When fed a canola oil-rich diet for 4.5 months, iePPARγKO mice had higher body lean mass than the WT mice. We conclude that intestinal epithelium PPARγ is activated preferentially by long chain unsaturated FAs compared to medium chain saturated FAs. Furthermore, we hypothesize that the iePPARγKO phenotype originates from altered lipid metabolism and release in epithelial cells, as well as changes in intestinal motility.
Mots-clé
Animals, Fatty Acids/metabolism, Intestinal Mucosa/metabolism, Lipid Metabolism/genetics, Lipid Metabolism/physiology, Male, Mice, Mice, Knockout, PPAR gamma/genetics, PPAR gamma/metabolism, PPARγ, intestine, lipid metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/01/2018 11:40
Dernière modification de la notice
20/08/2019 13:23
Données d'usage