Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner.
Details
Serval ID
serval:BIB_018771138153
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner.
Journal
Frontiers in medicine
ISSN
2296-858X (Print)
ISSN-L
2296-858X
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
6
Pages
88
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [ <sup>18</sup> F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [ <sup>18</sup> F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (<10 s) which allows for whole body scans with doses as low as 3 mGy. The mouse total-body PET subsystem uses a detector architecture based on continuous crystals, coupled to SiPM arrays and a readout based in rows and columns. The PET field of view is 150 mm axial and 80 mm transaxial. The high solid-angle coverage of the sample and the use of continuous crystals achieve a sensitivity of 9% (NEMA) that can be leveraged for use of low tracer doses and/or performing rapid scans. The low-dose imaging capabilities of the total-body PET subsystem were tested with NEMA phantoms, in tumor models, a mouse bone metabolism scan and a rat heart dynamic scan. The CT imaging capabilities were tested in mice and in a low contrast phantom. The PET low-dose phantom and animal experiments provide evidence that image quality suitable for preclinical PET studies is achieved. Furthermore, CT image contrast using low dose scan settings was suitable as a reference for PET scans. Total-body mouse PET/CT studies could be completed with total doses of <10 mGy.
Keywords
CT, PET, [18F]FDG, imaging, low dose, oncology, preclinical, total-body
Pubmed
Web of science
Open Access
Yes
Create date
14/06/2019 16:19
Last modification date
15/01/2021 7:08