Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway--therapeutic perspectives in cancer.
Nature Clinical Practice. Oncology
Publication types: Journal Article ; Review Publication Status: ppublish
The insulin-like growth factor 1 (IGF1) signaling pathway is implicated in the development of cancer. High levels of circulating IGF1 and certain genetic polymorphisms of IGF1 and IGFBP3 are associated with an increased risk of several common cancers. The IGF1 receptor (IGF1R) has been shown to be expressed in a wide range of tumors, and IGF1R signaling is crucial for tumor transformation and the survival of malignant cells. Several monoclonal antibodies and small-molecule inhibitors have been tested in preclinical studies and early-phase clinical studies. IGF1R signaling interferes with numerous growth factors and receptors such as VEGF and EGFR. In the experimental system, IGF1R signaling has been found to correlate with resistance to therapies based on the inhibition of EGFR and HER2. This Review highlights the most relevant studies in this exciting area of research, focusing in particular on the role of IGF1R in resistance to other receptor-targeted therapies for cancer.
Animals, Antibodies, Monoclonal/therapeutic use, Antineoplastic Agents/therapeutic use, Humans, Neoplasms/drug therapy, Neoplasms/physiopathology, Polymorphism, Genetic, Receptor Cross-Talk, Receptor Protein-Tyrosine Kinases/metabolism, Receptor, Epidermal Growth Factor/antagonists & inhibitors, Receptor, IGF Type 1/antagonists & inhibitors, Receptor, IGF Type 1/genetics, Signal Transduction
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