Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: the Swiss HIV Cohort Study

Détails

ID Serval
serval:BIB_013B48DAB2A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: the Swiss HIV Cohort Study
Périodique
Journal of Acquired Immune Deficiency Syndromes
Auteur(s)
Glass  T. R., De Geest  S., Weber  R., Vernazza  P. L., Rickenbach  M., Furrer  H., Bernasconi  E., Cavassini  M., Hirschel  B., Battegay  M., Bucher  H. C.
ISSN
1525-4135 (Print)
Statut éditorial
Publié
Date de publication
03/2006
Volume
41
Numéro
3
Pages
385-92
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
BACKGROUND: Adherence is one of the most crucial issues in the clinical management of HIV-infected patients receiving antiretroviral therapy (ART). METHODS: A 2-item adherence questionnaire was introduced into the Swiss HIV Cohort Study in July 2003. All 3607 eligible patients were on ART for > or =6 months and their current regimen for > or =1 month. Three definitions of nonadherence were considered: missing > or =1 dose, missing > or =2 doses, and taking <95% of doses in the past 4 weeks. RESULTS: Over 30% of patients reported missing > or =1 dose, 14.9% missed > or =2 doses, and 7.1% took <95% of doses in the previous 4 weeks. The rate of drug holidays was 5.8%. Whether using more or less conservative definitions of nonadherence, younger age, living alone, number of previous regimens, and boosted protease inhibitor regimens were independent factors associated with nonadherence. There was a significant association between optimal viral suppression and nonadherence as well as a significant linear trend in optimal viral suppression by missed doses. CONCLUSIONS: Younger age, lack of social support, and complexity of therapy are important factors that are related to nonadherence with ART. Investment in behavioral dimensions of HIV is crucial to improve adherence in ART recipients.
Mots-clé
Adult Age Factors Anti-HIV Agents/*administration & dosage/therapeutic use Antiretroviral Therapy, Highly Active Cohort Studies Female HIV Infections/*drug therapy Humans Life Style Male Questionnaires Risk Factors Treatment Refusal/*statistics & numerical data Viral Load
Pubmed
Web of science
Création de la notice
29/01/2008 9:52
Dernière modification de la notice
03/03/2018 13:14
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