Carrying out an interprofessional medication review to optimize the treatment of nursing home residents is interesting in more ways than one. This is evidenced by the practical case managed and described here by the medical and nursing team who decided and implemented several consequential medication changes. The discussions involved medical, nursing, and clinical pharmacy perspectives, which complemented each other to enhance the effectiveness and safety of the resident's treatment while considering their specific personal and clinical situation. This synergy has resulted in improved quality of care, concretely felt by the resident himself, but it also increased knowledge that can be transferred to improve the use of medicines of other residents in the facility.