Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.

Détails

ID Serval
serval:BIB_01343CED3787
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.
Périodique
Diabetologia
Auteur(s)
Lin X., Song K., Lim N., Yuan X., Johnson T., Abderrahmani A., Vollenweider P., Stirnadel H., Sundseth S.S., Lai E., Burns D.K., Middleton L.T., Roses A.D., Matthews P.M., Waeber G., Cardon L., Waterworth D.M., Mooser V.
ISSN
1432-0428[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
52
Numéro
4
Pages
600-608
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
AIMS/HYPOTHESIS: Several susceptibility genes for type 2 diabetes have been discovered recently. Individually, these genes increase the disease risk only minimally. The goals of the present study were to determine, at the population level, the risk of diabetes in individuals who carry risk alleles within several susceptibility genes for the disease and the added value of this genetic information over the clinical predictors. METHODS: We constructed an additive genetic score using the most replicated single-nucleotide polymorphisms (SNPs) within 15 type 2 diabetes-susceptibility genes, weighting each SNP with its reported effect. We tested this score in the extensively phenotyped population-based cross-sectional CoLaus Study in Lausanne, Switzerland (n = 5,360), involving 356 diabetic individuals. RESULTS: The clinical predictors of prevalent diabetes were age, BMI, family history of diabetes, WHR, and triacylglycerol/HDL-cholesterol ratio. After adjustment for these variables, the risk of diabetes was 2.7 (95% CI 1.8-4.0, p = 0.000006) for individuals with a genetic score within the top quintile, compared with the bottom quintile. Adding the genetic score to the clinical covariates improved the area under the receiver operating characteristic curve slightly (from 0.86 to 0.87), yet significantly (p = 0.002). BMI was similar in these two extreme quintiles. CONCLUSIONS/INTERPRETATION: In this population, a simple weighted 15 SNP-based genetic score provides additional information over clinical predictors of prevalent diabetes. At this stage, however, the clinical benefit of this genetic information is limited.
Mots-clé
Colaus Study
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/03/2009 12:13
Dernière modification de la notice
08/05/2019 13:41
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