Rational design of an organometallic glutathione transferase inhibitor.
Details
Serval ID
serval:BIB_0133BD089CFC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rational design of an organometallic glutathione transferase inhibitor.
Journal
Angewandte Chemie
ISSN
1521-3773[electronic]
Publication state
Published
Issued date
2009
Volume
48
Number
21
Pages
3854-3857
Language
english
Abstract
Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods.
Pubmed
Web of science
Create date
18/05/2009 18:22
Last modification date
20/08/2019 13:23