Circadian regulation of islet genes involved in insulin production and secretion

Détails

ID Serval
serval:BIB_0132435CECDD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Circadian regulation of islet genes involved in insulin production and secretion
Périodique
Molecular and Cellular Endocrinology
Auteur(s)
Allaman-Pillet N., Roduit R., Oberson A., Abdelli S., Ruiz J., Beckmann J. S., Schorderet D. F., Bonny C.
ISSN
0303-7207 (Print)
Statut éditorial
Publié
Date de publication
10/2004
Peer-reviewed
Oui
Volume
226
Numéro
1-2
Pages
59-66
Langue
anglais
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 29
Résumé
Both transcription factors albumin site d-binding protein (DBP) and thyrotroph embryonic factor (TEF) are elements of the "cell-clock". Their circadian accumulation in suprachiasmatic nucleus (SCN) and peripheral tissues such as liver, kidney and lung is thought to participate in controlling circadian regulation of downstream genes. TEF and DBP control elements have never been investigated in the insulin-secreting cells, but impairment of the circadian rhythm of the beta-cells might be involved in the development of diabetic state as type 2 diabetics have lost daily temporal variations of insulin secretion. We investigated the expression pattern of TEF and DBP in insulin-secreting cells. TEF and DBP transcripts are expressed at extremely high levels in human pancreatic islets compared to other tissues, suggesting a potentially important circadian regulation of these cells. Both TEF and DPB accumulate in a circadian way in insulin-secreting cells after a serum shock known to restore circadian rhythms in cultured cells. In addition, the expression of islet-specific genes involved in glucose sensing (glucose transporter 2 (Glut2), glucokinase), insulin production (insulin) and secretion (migration inhibitory factor (MIF), somatostatin and syntaxin 1A) were modulated in the same daily rhythm as well. The circadian deregulation of these genes could therefore participate in the diabetic state development.
Mots-clé
Antigens, Surface/metabolism Basic-Leucine Zipper Transcription Factors *Circadian Rhythm DNA-Binding Proteins/*metabolism Gene Expression Regulation Glucokinase/metabolism Glucose Transporter Type 2 Humans Insulin/*biosynthesis/*secretion Islets of Langerhans/*metabolism Macrophage Migration-Inhibitory Factors/metabolism Monosaccharide Transport Proteins/genetics/metabolism Nerve Tissue Proteins/metabolism Promoter Regions (Genetics) Somatostatin/metabolism Suprachiasmatic Nucleus/metabolism Syntaxin 1 Transcription Factors/*metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 17:17
Dernière modification de la notice
03/03/2018 13:14
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