Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia.

Détails

ID Serval
serval:BIB_012EAAA6447D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia.
Périodique
Neurobiology of disease
Auteur(s)
Cabungcal J.H., Nicolas D., Kraftsik R., Cuénod M., Do K.Q., Hornung J.P.
ISSN
0969-9961
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
22
Numéro
3
Pages
624-37
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
A series of studies in schizophrenic patients report a decrease of glutathione (GSH) in prefrontal cortex (PFC) and cerebrospinal fluid, a decrease in mRNA levels for two GSH synthesizing enzymes and a deficit in parvalbumin (PV) expression in a subclass of GABA neurons in PFC. GSH is an important redox regulator, and its deficit could be responsible for cortical anomalies, particularly in regions rich in dopamine innervation. We tested in an animal model if redox imbalance (GSH deficit and excess extracellular dopamine) during postnatal development would affect PV-expressing neurons. Three populations of interneurons immunolabeled for calcium-binding proteins were analyzed quantitatively in 16-day-old rat brain sections. Treated rats showed specific reduction in parvalbumin immunoreactivity in the anterior cingulate cortex, but not for calbindin and calretinin. These results provide experimental evidence for the critical role of redox regulation in cortical development and validate this animal model used in schizophrenia research.
Mots-clé
Animals, Brain Chemistry, Calcium-Binding Protein, Vitamin D-Dependent, Disease Models, Animal, Dopamine, Extracellular Fluid, Glutathione, Immunohistochemistry, Male, Neurons, Parvalbumins, Prefrontal Cortex, Rats, Schizophrenia, gamma-Aminobutyric Acid
Pubmed
Web of science
Création de la notice
10/03/2008 11:49
Dernière modification de la notice
03/03/2018 13:14
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