Notch1 and T-cell development: insights from conditional knockout mice.

Détails

ID Serval
serval:BIB_012B2C9E803D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Notch1 and T-cell development: insights from conditional knockout mice.
Périodique
Trends in immunology
Auteur(s)
MacDonald H.R., Wilson A., Radtke F.
ISSN
1471-4906
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
22
Numéro
3
Pages
155-160
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Notch proteins influence cell-fate decisions in many developmental systems. Gain-of-function studies have suggested a crucial role for Notch1 signaling at several stages during lymphocyte development, including the B/T, alphabeta/gammadelta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch1 gene.
Mots-clé
Animals, B-Lymphocytes/cytology, B-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/cytology, Cell Differentiation, Cell Lineage, Membrane Proteins/genetics, Membrane Proteins/physiology, Mice, Mice, Knockout, Receptor, Notch1, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Cell Surface, Signal Transduction/physiology, T-Lymphocytes/cytology, T-Lymphocytes/immunology, Transcription Factors
Pubmed
Web of science
Création de la notice
28/01/2008 11:39
Dernière modification de la notice
20/08/2019 12:23
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