Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection

Détails

ID Serval
serval:BIB_0101B41AE49B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Graziosi  C., Gantt  K. R., Vaccarezza  M., Demarest  J. F., Daucher  M., Saag  M. S., Shaw  G. M., Quinn  T. C., Cohen  O. J., Welbon  C. C., Pantaleo  G., Fauci  A. S.
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
04/1996
Volume
93
Numéro
9
Pages
4386-91
Notes
Journal Article --- Old month value: Apr 30
Résumé
In the present study, we have determined the kinetics of constitutive expression of a panel of cytokines [interleukin (IL) 2, IL-4, IL-6, IL-10, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha)] in sequential peripheral blood mononuclear cell samples from nine individuals with primary human immunodeficiency virus infection. Expression of IL-2 and IL-4 was barely detected in peripheral blood mononuclear cells. However, substantial levels of IL-2 expression were found in mononuclear cells isolated from lymph node. Expression of IL-6 was detected in only three of nine patients, and IL-6 expression was observed when transition from the acute to the chronic phase had already occurred. Expression of IL-10 and TNF-alpha was consistently observed in all patients tested, and levels of both cytokines were either stable or progressively increased over time. Similar to IL-10 and TNF-alpha, IFN-gamma expression was detected in all patients; however, in five of nine patients, IFN-gamma expression peaked very early during primary infection. The early peak in IFN-gamma expression coincided with oligoclonal expansions of CD8+ T cells in five of six patients, and CD8+ T cells mostly accounted for the expression of this cytokine. These results indicate that high levels of expression of proinflammatory cytokines are associated with primary infection and that the cytokine response during this phase of infection is strongly influenced by oligoclonal expansions of CD8+ T cells.
Mots-clé
Cells, Cultured Cytokines/*biosynthesis Gene Expression Regulation, Viral HIV Infections/*immunology *Hiv-1 Humans Interferon Type II/biosynthesis Interleukin-10/biosynthesis Interleukin-2/biosynthesis Interleukin-4/biosynthesis Interleukin-6/biosynthesis Kinetics Lymph Nodes/immunology Lymphocytes/*immunology RNA, Messenger/analysis/biosynthesis Receptors, Antigen, T-Cell, alpha-beta T-Lymphocyte Subsets/immunology Time Factors Tumor Necrosis Factor-alpha/biosynthesis
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 14:58
Dernière modification de la notice
20/08/2019 12:23
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