Giant warts in a kidney transplant patient: regression with sirolimus.

Détails

ID Serval
serval:BIB_00F7CD81351B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Giant warts in a kidney transplant patient: regression with sirolimus.
Périodique
British Journal of Dermatology
Auteur(s)
Kostaki M., Venetz J.P., Nseir G., Meylan P., Sahli R., Pascual M., Laffitte E.
ISSN
1365-2133[electronic], 0007-0963[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
162
Numéro
5
Pages
1148-1150
Langue
anglais
Notes
Publication types: Case Reports ; Letter Publication Status: ppublish
Résumé
Purpose: Recent reports have suggested that intraabdominal
postoperative infection is associated with higher
rates of overall and local recurrence and cancer-specific mortality.
However, the mechanisms responsible for this association
are unknown. We hypothesized that the greater
inflammatory response in patients with postoperative intraabdominal
infection is associated to an increase in local and
systemic angiogenesis.
Methods: We designed a prospective cohorts study with
matched controls. Patients with postoperative intra-abdominal
infection (abscess and/or anastomotic leakage) (group 1;
n=17) after elective colorectal cancer resection operated on
for cure were compared to patients with an uncomplicated
postoperative course (group 2; n=17). IL-6 and VEGF levels
were determined by ELISA in serum and peritoneal fluid at
baseline, 48 hours and postoperative day 4 or at the time
the peritoneal infection occurred.
Results: No differences were observed in age, gender, preoperative
CEA, tumor stage and location and type of procedure
performed. Although there were no differences in
serum IL-6 levels at 48 hours, this pro-inflammatory
cytokine was higher in group 1 on postoperative day 4
(group 1: 21533 + 27900 vs. group 2: 1130 + 3563 pg/ml; p
< 0.001). Serum VEGF levels were higher in group 1 on
postoperative day 4 (group 1: 1212 + 1025 vs. group 2: 408
+ 407 pg/ml; p < 0.01). Peritoneal fluid VEGF levels were
also higher in group 1 at 48 hours (group 1: 4857 + 4384 vs.
group 2: 630 + 461 pg/ml; p < 0.001) and postoperative day
4 (group 1: 32807 + 98486 vs. group 2: 1002 + 1229 pg/ml;
p < 0.001). A positive correlation between serum IL-6 and
VEGF serum levels was observed on postoperative day 4
(r=0.7; p<0.01).
Conclusions: These results suggest that not only the
inflammatory response but also the angiogenic pathways are
stimulated in patients with intra-abdominal infection after
surgery for colorectal cancer. The implications of this finding
on long-term follow-up need to be evaluated.
Mots-clé
Humans, Immunocompromised Host, Immunosuppressive Agents/therapeutic use, Kidney Transplantation/immunology, Male, Middle Aged, Sirolimus/therapeutic use, Warts/drug therapy
Pubmed
Web of science
Création de la notice
27/07/2010 11:35
Dernière modification de la notice
20/08/2019 13:23
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