Implantation markers and endometriosis
Details
Serval ID
serval:BIB_0098A625167A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Implantation markers and endometriosis
Journal
Reproductive Biomedicine Online
ISSN
1472-6483
Publication state
Published
Issued date
10/2005
Peer-reviewed
Oui
Volume
11
Number
4
Pages
464-8
Notes
Journal Article --- Old month value: Oct
Abstract
The receptive phase of the endometrium seems to occur in close association with the appearance of pinopodes and endometrial integrins that may be activated by the interleukin-1 system (IL-1). Embryo attachment is the result of adhesion protein expression, and the invasion of the embryo is governed by proteolytic enzymes. Leukaemia inhibitory factor (LIF) is produced by natural killer lymphocytes that interact with the invading trophoblast. This may activate urokinase plasminogen activator (uPA) and gelatinase enzymes, which play a crucial role in trophoblast invasion. Oestrogen stimulates, while progesterone inhibits, LIF. The role of endometrial contractility in displacing human embryos from the Fallopian tube to the lumen cavity of the uterus or vagina in terms of pregnancy or wastage is still a matter of discussion. Endometriosis and its associated abnormal uterine contractions may be also linked to implantation failure. Unless new evidence emerges to indicate otherwise, it can be assumed that progesterone is, either in a direct (non-genomic: contractility) or indirect (genomic: decidualization) manner, the only determinant of endometrial priming necessary for embryo nidation.
Keywords
Biological Markers/metabolism
*Embryo Implantation
Endometriosis/complications/*diagnosis/metabolism
Endometrium/pathology
Estrogens/metabolism
Female
Fertilization
Hormones/metabolism
Humans
Infertility, Female
Interleukin-1/*metabolism
Interleukin-6/metabolism
Killer Cells, Natural/metabolism
Leukemia Inhibitory Factor
Lymphocytes/metabolism
Models, Biological
Ovulation
Pregnancy
Urinary Plasminogen Activator/metabolism
Uterine Contraction
Pubmed
Web of science
Open Access
Yes
Create date
28/02/2008 12:37
Last modification date
20/08/2019 13:22