Neurological Adverse Events Associated with Immune Checkpoint Inhibitors: Diagnosis and Management.

Details

Serval ID
serval:BIB_0037F78B4822
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Neurological Adverse Events Associated with Immune Checkpoint Inhibitors: Diagnosis and Management.
Journal
Current neurology and neuroscience reports
Author(s)
Astaras C., de Micheli R., Moura B., Hundsberger T., Hottinger A.F.
ISSN
1534-6293 (Electronic)
ISSN-L
1528-4042
Publication state
Published
Issued date
01/02/2018
Peer-reviewed
Oui
Volume
18
Number
1
Pages
3
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Immune checkpoint inhibitors represent a major step forward in the field of oncologic immunotherapy these last years and have significantly increased survival of cancer patients in an ever-growing number of indications. These agents block specific immune checkpoint molecules (programmed cell death protein 1 and its ligand as well as cytotoxic T-lymphocyte-associated antigen 4) that normally downregulate the immune response. These new agents show a specific range of adverse effects induced by abnormal immunologic activation.
Many different neurologic adverse events have been described, including encephalitis, myelopathy, aseptic meningitis, meningoradiculitis, Guillain-Barré-like syndrome, peripheral neuropathy (including mononeuropathy, mononeuritis multiplex, and polyneuropathy) as well as myasthenic syndrome. Immune checkpoint inhibitors have shown promising results in cancer but can possibly induce autoimmune disorders. Although rare, neurological adverse events require prompt recognition and treatment to avoid substantial morbidity.
Keywords
Antineoplastic Agents, Immunological/adverse effects, Autoimmune Diseases of the Nervous System/chemically induced, Autoimmune Diseases of the Nervous System/diagnosis, Autoimmune Diseases of the Nervous System/therapy, Disease Management, Humans, Anti-CTLA-4, Anti-PD-1, Encephalitis, Immune checkpoint inhibitors, Meningitis, Myositis, Neurological adverse events, Polyneuropathy
Pubmed
Web of science
Create date
08/02/2018 18:54
Last modification date
20/08/2019 12:22
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