The role of Notch in the differentiation of CD4⁺ T helper cells.

Détails

ID Serval
serval:BIB_002AEA625D37
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The role of Notch in the differentiation of CD4⁺ T helper cells.
Périodique
Current Topics in Microbiology and Immunology
Auteur(s)
Auderset F., Coutaz M., Tacchini-Cottier F.
ISSN
0070-217X (Print)
ISSN-L
0070-217X
Statut éditorial
Publié
Date de publication
2012
Volume
360
Pages
115-134
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
CD4⁺ T helper cells are playing critical roles in host defense to pathogens and in the maintenance of immune homeostasis. Naïve CD4⁺T cells, upon antigen-specific recognition, receive signals to differentiate into distinct effector T helper cell subsets characterized by their pattern of cytokine production and specific immune functions. A tight balance between these different subsets ensures proper control of the immune response. There is increasing evidence revealing an important role for Notch signaling in the regulation of CD4⁺T helper cell differentiation or function in the periphery. However, the exact mechanisms involved remain unclear and appear contradictory. In this review, we summarize current knowledge and discuss recent advances in the field to reconcile different views on the role of Notch signaling in the differentiation of functional T helper subsets.
Pubmed
Web of science
Création de la notice
19/12/2012 11:56
Dernière modification de la notice
20/08/2019 13:22
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