Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission
Détails
ID Serval
serval:BIB_FFB433AD725A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Human immunodeficiency virus (HIV) infection in CD4+ T lymphocytes genetically deficient in LFA-1: LFA-1 is required for HIV-mediated cell fusion but not for viral transmission
Périodique
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
02/1991
Volume
173
Numéro
2
Pages
511-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 1
Research Support, Non-U.S. Gov't --- Old month value: Feb 1
Résumé
In the present study, we demonstrated that expression of the LFA-1 molecule is necessary for cell fusion and syncytia formation in human immunodeficiency virus (HIV)-infected CD4+ T lymphocytes. In contrast, the lack of expression of LFA-1 does not influence significantly cell-to-cell transmission of HIV. In fact, LFA-1- T lymphocytes obtained from a leukocyte adhesion deficiency patient were unable to fuse and form syncytia when infected with HIV-1 or HIV-2, despite the fact that efficiency of HIV infection (i.e., virus entry, HIV spreading, and levels of virus replication) was comparable with that observed in LFA-1+ T lymphocytes. In addition, we provide evidence that LFA-1 by mediating cell fusion contributes to the depletion of HIV-infected CD4+ T lymphocytes in vitro.
Mots-clé
Antibodies, Monoclonal
CD4-Positive T-Lymphocytes/*microbiology
Cell Fusion
Cells, Cultured
Genes, Viral/genetics
Giant Cells
HIV-1/genetics/*physiology
HIV-2/genetics/*physiology
Humans
Lymphocyte Activation
Lymphocyte Function-Associated Antigen-1/deficiency/genetics/*physiology
Phytohemagglutinins
Polymerase Chain Reaction
Virus Replication
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:58
Dernière modification de la notice
20/08/2019 17:29