A molecular profile of T-cell exhaustion in cancer.

Détails

Ressource 1Télécharger: BIB_FEDF76FCECC4.P001.pdf (268.83 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_FEDF76FCECC4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
A molecular profile of T-cell exhaustion in cancer.
Périodique
Oncoimmunology
Auteur(s)
Speiser D.E.
ISSN
2162-4011 (Print)
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
1
Numéro
3
Pages
369-371
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE
EDITORIAL
Résumé
The first gene profiling study of cancer-specific CD8+ T-cells demonstrates that lymphocyte dysfunction in cancer tissue is due to multiple molecular alterations,(1) similar as in "exhausted" T-cells in chronic infection.(2) The data suggest novel drug targets, and show that T-cell exhaustion is reversible and limited to anatomical sites of disease.
Pubmed
Open Access
Oui
Création de la notice
22/11/2012 14:24
Dernière modification de la notice
20/08/2019 16:29
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