Structural biology of hepatitis C virus

Détails

ID Serval
serval:BIB_FE819FD5C3D5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Structural biology of hepatitis C virus
Périodique
Hepatology
Auteur(s)
Penin  F., Dubuisson  J., Rey  F. A., Moradpour  D., Pawlotsky  J. M.
ISSN
0270-9139 (Print)
Statut éditorial
Publié
Date de publication
01/2004
Volume
39
Numéro
1
Pages
5-19
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jan
Résumé
Hepatitis C virus (HCV) causes acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Studies of this virus have been hampered by the lack of a productive cell culture system; most information thus has been obtained from analysis of the HCV genome, heterologous expression systems, in vitro and in vivo models, and structural analyses. Structural analyses of HCV components provide an essential framework for understanding of the molecular mechanisms of HCV polyprotein processing, RNA replication, and virion assembly and may contribute to a better understanding of the pathogenesis of hepatitis C. Moreover, these analyses should allow the identification of novel targets for antiviral intervention and development of new strategies to prevent and combat viral hepatitis. This article reviews the current knowledge of HCV structural biology.
Mots-clé
Hepacivirus/*genetics/*growth & development Hepatitis C/*virology Humans Viral Proteins/*chemistry/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
20/08/2019 16:29
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