Structural biology of hepatitis C virus
Details
Serval ID
serval:BIB_FE819FD5C3D5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Structural biology of hepatitis C virus
Journal
Hepatology
ISSN
0270-9139 (Print)
Publication state
Published
Issued date
01/2004
Volume
39
Number
1
Pages
5-19
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jan
Research Support, Non-U.S. Gov't
Review --- Old month value: Jan
Abstract
Hepatitis C virus (HCV) causes acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Studies of this virus have been hampered by the lack of a productive cell culture system; most information thus has been obtained from analysis of the HCV genome, heterologous expression systems, in vitro and in vivo models, and structural analyses. Structural analyses of HCV components provide an essential framework for understanding of the molecular mechanisms of HCV polyprotein processing, RNA replication, and virion assembly and may contribute to a better understanding of the pathogenesis of hepatitis C. Moreover, these analyses should allow the identification of novel targets for antiviral intervention and development of new strategies to prevent and combat viral hepatitis. This article reviews the current knowledge of HCV structural biology.
Keywords
Hepacivirus/*genetics/*growth & development
Hepatitis C/*virology
Humans
Viral Proteins/*chemistry/genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 17:05
Last modification date
20/08/2019 17:29