POLYRETINA restores light responses in vivo in blind Göttingen minipigs.
Détails
Télécharger: 35760775_BIB_FDA619487A1D.pdf (8189.95 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_FDA619487A1D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
POLYRETINA restores light responses in vivo in blind Göttingen minipigs.
Périodique
Nature communications
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
27/06/2022
Peer-reviewed
Oui
Volume
13
Numéro
1
Pages
3678
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Retinal prostheses hold the potential for artificial vision in blind people affected by incurable diseases of the outer retinal layer. Available technologies provide only a small field of view: a significant limitation for totally blind people. To overcome this problem, we recently proposed a large and high-density photovoltaic epiretinal device, known as POLYRETINA. Here, we report the in vivo assessment of POLYRETINA. First, we characterise a model of chemically-induced blindness in Göttingen minipigs. Then, we develop and test a minimally invasive injection procedure to insert the large epiretinal implant into the eye. Last, we show that POLYRETINA restores light-evoked cortical responses in blind animals at safe irradiance levels. These results indicate that POLYRETINA holds the potential for artificial vision in totally blind patients affected by retinitis pigmentosa.
Mots-clé
Animals, Blindness, Humans, Retinitis Pigmentosa, Swine, Swine, Miniature, Visual Prosthesis, Visually Impaired Persons
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/07/2022 12:33
Dernière modification de la notice
22/03/2024 9:24