Twisting in a crowd

Détails

Ressource 1Télécharger: Dubochet1993-TrendsinCellBio-PV.pdf (947.46 [Ko])
Etat: Public
Version: Final published version
Document(s) secondaire(s)
Sous embargo indéterminé.
Etat: Public
Version: Supplementary document
ID Serval
serval:BIB_FB55585DEAE7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Twisting in a crowd
Périodique
Trends in Cell Biology
Auteur(s)
Dubochet  J.
ISSN
0962-8924 (Print)
Statut éditorial
Publié
Date de publication
01/1993
Peer-reviewed
Oui
Volume
3
Numéro
1
Pages
1-3
Langue
anglais
Notes
Journal Article --- Old month value: Jan
Résumé
Given our current understanding of nuclear structure, it is difficult to imagine how the nucleus performs its varied functions and controls the traffic of its many components. For example, how can densely packed chromatin be transcribed without the helical nature of the DNA resulting in entangled DNA and RNA and a stalled RNA polymerase? Here, Jacques Dubochet discusses a model of transcription in which DNA rotates around its axis, rather than RNA polymerase rotating around the DNA. Furthermore, he suggests that a view of chromatin as 'liquid' may help in understanding a wide range of nuclear functions.
Pubmed
Création de la notice
24/01/2008 11:25
Dernière modification de la notice
20/08/2019 17:26
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