Twisting in a crowd

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Ressource 1Download: Dubochet1993-TrendsinCellBio-PV.pdf (947.46 [Ko])
State: Public
Version: Final published version
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State: Public
Version: Supplementary document
Serval ID
serval:BIB_FB55585DEAE7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Twisting in a crowd
Journal
Trends in Cell Biology
Author(s)
Dubochet  J.
ISSN
0962-8924 (Print)
Publication state
Published
Issued date
01/1993
Peer-reviewed
Oui
Volume
3
Number
1
Pages
1-3
Language
english
Notes
Journal Article --- Old month value: Jan
Abstract
Given our current understanding of nuclear structure, it is difficult to imagine how the nucleus performs its varied functions and controls the traffic of its many components. For example, how can densely packed chromatin be transcribed without the helical nature of the DNA resulting in entangled DNA and RNA and a stalled RNA polymerase? Here, Jacques Dubochet discusses a model of transcription in which DNA rotates around its axis, rather than RNA polymerase rotating around the DNA. Furthermore, he suggests that a view of chromatin as 'liquid' may help in understanding a wide range of nuclear functions.
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Create date
24/01/2008 11:25
Last modification date
20/08/2019 17:26
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