Phenotype-dependent inhibition of human alpha 1-antitrypsin by 1,6-hexane diamine in vitro

Détails

ID Serval
serval:BIB_F6735C96A136
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Phenotype-dependent inhibition of human alpha 1-antitrypsin by 1,6-hexane diamine in vitro
Périodique
Biochemistry International
Auteur(s)
Berode M., Leuenberger P., Savolainen H.
ISSN
0158-5231 (Print)
Statut éditorial
Publié
Date de publication
07/1988
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
141-145
Langue
anglais
Notes
In Vitro Journal Article --- Old month value: Jul
Résumé
Blood donors and patients from pulmonary wards gave serum specimens for the assay of their alpha 1-antitrypsin activity and phenotype. The same specimens were then incubated at the room temperature overnight with increasing concentrations of 1,6-hexane diamine. The 5 mM amine concentration caused a significant decrease in heterozygous antitrypsins (M1M2, M1M3, M2M3 and M1S) activity while it was less in the homozygous (M1M1 and M2M2) antitrypsin phenotypes. The SS and ZZ phenotypes showed a very low initial activity which was, however, further reduced. Analysis for the antitrypsin protein showed a simultaneous loss of its activity. The data suggest that heterozygous antitrypsin carriers may be more prone to the effects of inhaled amines despite their 'normal' phenotypic constitution.
Mots-clé
Diamines/*pharmacology Heterozygote Homozygote Humans Isoelectric Focusing Phenotype alpha 1-Antitrypsin/*genetics
Pubmed
Web of science
Création de la notice
25/01/2008 10:49
Dernière modification de la notice
20/08/2019 17:22
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