Immune sensing of nucleic acids in inflammatory skin diseases.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
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ID Serval
serval:BIB_F4985A6A9909
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Immune sensing of nucleic acids in inflammatory skin diseases.
Périodique
Seminars In Immunopathology
Auteur⸱e⸱s
Demaria O., Di Domizio J., Gilliet M.
ISSN
1863-2300 (Electronic)
ISSN-L
1863-2297
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
36
Numéro
5
Pages
519-529
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish; pdf : REVIEW
Résumé
Endosomal and cytosolic nucleic acid receptors are important immune sensors required for the detection of infecting or replicating viruses. The intracellular location of these receptors allows viral recognition and, at the same time, avoids unnecessary immune activation to self-nucleic acids that are continuously released by dying host cells. Recent evidence, however, indicates that endogenous factors such as anti-microbial peptides have the ability to break this protective mechanism. Here, we discuss these factors and illustrate how they drive inflammatory responses by promoting immune recognition of self-nucleic acids in skin wounds and inflammatory skin diseases such as psoriasis and lupus.
Pubmed
Web of science
Création de la notice
06/11/2014 19:16
Dernière modification de la notice
09/09/2021 6:15
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