Immune sensing of nucleic acids in inflammatory skin diseases.

Details

Serval ID
serval:BIB_F4985A6A9909
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immune sensing of nucleic acids in inflammatory skin diseases.
Journal
Seminars In Immunopathology
Author(s)
Demaria O., Di Domizio J., Gilliet M.
ISSN
1863-2300 (Electronic)
ISSN-L
1863-2297
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
36
Number
5
Pages
519-529
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish; pdf : REVIEW
Abstract
Endosomal and cytosolic nucleic acid receptors are important immune sensors required for the detection of infecting or replicating viruses. The intracellular location of these receptors allows viral recognition and, at the same time, avoids unnecessary immune activation to self-nucleic acids that are continuously released by dying host cells. Recent evidence, however, indicates that endogenous factors such as anti-microbial peptides have the ability to break this protective mechanism. Here, we discuss these factors and illustrate how they drive inflammatory responses by promoting immune recognition of self-nucleic acids in skin wounds and inflammatory skin diseases such as psoriasis and lupus.
Pubmed
Web of science
Create date
06/11/2014 20:16
Last modification date
20/08/2019 17:21
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