Testing mode of inheritance of a candidate mutation at a quantitative trait locus

Détails

ID Serval
serval:BIB_F234259861AC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Testing mode of inheritance of a candidate mutation at a quantitative trait locus
Périodique
Human Heredity
Auteur⸱e⸱s
Rabinowitz  D., Zanchi  A., Schaumberg  D., Krolewski  A.
ISSN
0001-5652
Statut éditorial
Publié
Date de publication
06/2000
Peer-reviewed
Oui
Volume
50
Numéro
3
Pages
184-8
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: May-Jun
Résumé
Here is presented an approach to testing whether the effect of a candidate gene on a quantitative trait is dominant and for testing whether the effect is recessive. The approach uses parental genotype information in nuclear families to adjust for bias due to population admixture. The approach is applicable regardless of the nature of the sampling. The results of an application of the methods to a candidate mutation for diabetic nephropathy are used for illustration.
Mots-clé
Diabetes Mellitus, Type 1/genetics Diabetic Nephropathies/*genetics Genes, Dominant Genes, Recessive Genotype Humans Linkage (Genetics) *Models, Genetic Models, Statistical *Mutation *Quantitative Trait, Heritable
Pubmed
Web of science
Création de la notice
11/02/2008 9:30
Dernière modification de la notice
20/08/2019 16:19
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