Testing mode of inheritance of a candidate mutation at a quantitative trait locus

Details

Serval ID
serval:BIB_F234259861AC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Testing mode of inheritance of a candidate mutation at a quantitative trait locus
Journal
Human Heredity
Author(s)
Rabinowitz  D., Zanchi  A., Schaumberg  D., Krolewski  A.
ISSN
0001-5652
Publication state
Published
Issued date
06/2000
Peer-reviewed
Oui
Volume
50
Number
3
Pages
184-8
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: May-Jun
Abstract
Here is presented an approach to testing whether the effect of a candidate gene on a quantitative trait is dominant and for testing whether the effect is recessive. The approach uses parental genotype information in nuclear families to adjust for bias due to population admixture. The approach is applicable regardless of the nature of the sampling. The results of an application of the methods to a candidate mutation for diabetic nephropathy are used for illustration.
Keywords
Diabetes Mellitus, Type 1/genetics Diabetic Nephropathies/*genetics Genes, Dominant Genes, Recessive Genotype Humans Linkage (Genetics) *Models, Genetic Models, Statistical *Mutation *Quantitative Trait, Heritable
Pubmed
Web of science
Create date
11/02/2008 10:30
Last modification date
20/08/2019 17:19
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