Transscleral Optical Phase Imaging of the Human Retina.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_F1C5D31AEDAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Transscleral Optical Phase Imaging of the Human Retina.
Périodique
Nature photonics
Auteur⸱e⸱s
Laforest T., Künzi M., Kowalczuk L., Carpentras D., Behar-Cohen F., Moser C.
ISSN
1749-4885 (Print)
ISSN-L
1749-4885
Statut éditorial
Publié
Date de publication
07/2020
Peer-reviewed
Oui
Volume
14
Numéro
7
Pages
439-445
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In-vivo observation of the human retina at the cellular level is crucial to detect the first signs of retinal diseases and properly treat them. Despite the phenomenal advances in adaptive optics (AO) systems, clinical imaging of many retinal cells is still elusive due to the low signal-to-noise ratio induced by transpupillary illumination. We present a transscleral optical phase imaging (TOPI) method, which relies on high-angle oblique illumination of the retina, combined with AO, to enhance cell contrast. Examination of eleven healthy volunteer eyes, without pupil dilation, shows the ability of this method to produce in-vivo images of retinal cells, from the retinal pigment epithelium to the nerve fibre layer. This method also allows the generation of high-resolution label-free ex-vivo phase images of flat-mounted retinas. The 4.4°x 4.4° field-of-view in-vivo images are recorded in less than 10 seconds, opening new avenues in the exploration of healthy and diseased retinas.
Mots-clé
Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Pubmed
Web of science
Financement(s)
Autre / EIT Health_ASSESS
Création de la notice
05/05/2020 9:54
Dernière modification de la notice
30/04/2021 7:16
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