Proton beam irradiation of choroidal hemangiomas

Détails

ID Serval
serval:BIB_EFCBFAC712E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Proton beam irradiation of choroidal hemangiomas
Périodique
American Journal of Ophthalmology
Auteur(s)
Zografos  L., Egger  E., Bercher  L., Chamot  L., Munkel  G.
ISSN
0002-9394 (Print)
Statut éditorial
Publié
Date de publication
08/1998
Volume
126
Numéro
2
Pages
261-8
Notes
Journal Article --- Old month value: Aug
Résumé
PURPOSE: To present a large series of choroidal hemangiomas treated with proton beam irradiation and to describe the treatment outcomes. METHODS: We treated 54 eyes of 53 patients with choroidal hemangioma. The lesions consisted of 48 circumscribed hemangiomas and six diffuse hemangiomas in patients with Sturge-Weber syndrome. The total applied dose was 27.3 Gy in four eyes, 22.7 Gy in three eyes, and 16.4 Gy to 18.2 Gy in 47 eyes. RESULTS: The retina reattached within six months after treatment in all 54 eyes and no recurrence of the secondary retinal detachment occurred within the follow-up period of 6 months to 9 years. Tumors treated with the higher doses regressed faster than tumors treated with the lower doses, but radiation-induced complications of the optic nerve appeared in all four eyes treated with a total dose of 27.3 Gy. Of 31 eyes treated with 16.4 to 18.2 Gy and followed for more than 1 year, 22 had an improvement in their visual acuity, and nine retained the same visual acuity. At the last follow-up examination, the best-corrected visual acuity was 20/20 or better in nine eyes, 20/40 to 20/25 in 13 eyes, 20/100 to 20/50 in six eyes, and 20/200 or less in three eyes. CONCLUSIONS: Proton beam irradiation of choroidal hemangiomas appears to be a valid therapeutic alternative. A total proton dose ranging from 16.4 to 18.2 Gy applied in four daily fractions seems adequate to ensure local control of both tumor and secondary retinal detachment.
Mots-clé
Adult Aged Choroid Neoplasms/etiology/pathology/*radiotherapy Dose Fractionation Female Follow-Up Studies Hemangioma, Capillary/etiology/pathology/*radiotherapy Humans Male Middle Aged Optic Nerve/radiation effects Optic Nerve Diseases/etiology *Protons/adverse effects Radiation Injuries/etiology Radiotherapy Dosage Retinal Detachment/etiology/physiopathology Sturge-Weber Syndrome/complications Visual Acuity
Pubmed
Web of science
Création de la notice
28/01/2008 14:09
Dernière modification de la notice
20/08/2019 17:17
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