Proton beam irradiation of choroidal hemangiomas
Details
Serval ID
serval:BIB_EFCBFAC712E4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Proton beam irradiation of choroidal hemangiomas
Journal
American Journal of Ophthalmology
ISSN
0002-9394 (Print)
Publication state
Published
Issued date
08/1998
Volume
126
Number
2
Pages
261-8
Notes
Journal Article --- Old month value: Aug
Abstract
PURPOSE: To present a large series of choroidal hemangiomas treated with proton beam irradiation and to describe the treatment outcomes. METHODS: We treated 54 eyes of 53 patients with choroidal hemangioma. The lesions consisted of 48 circumscribed hemangiomas and six diffuse hemangiomas in patients with Sturge-Weber syndrome. The total applied dose was 27.3 Gy in four eyes, 22.7 Gy in three eyes, and 16.4 Gy to 18.2 Gy in 47 eyes. RESULTS: The retina reattached within six months after treatment in all 54 eyes and no recurrence of the secondary retinal detachment occurred within the follow-up period of 6 months to 9 years. Tumors treated with the higher doses regressed faster than tumors treated with the lower doses, but radiation-induced complications of the optic nerve appeared in all four eyes treated with a total dose of 27.3 Gy. Of 31 eyes treated with 16.4 to 18.2 Gy and followed for more than 1 year, 22 had an improvement in their visual acuity, and nine retained the same visual acuity. At the last follow-up examination, the best-corrected visual acuity was 20/20 or better in nine eyes, 20/40 to 20/25 in 13 eyes, 20/100 to 20/50 in six eyes, and 20/200 or less in three eyes. CONCLUSIONS: Proton beam irradiation of choroidal hemangiomas appears to be a valid therapeutic alternative. A total proton dose ranging from 16.4 to 18.2 Gy applied in four daily fractions seems adequate to ensure local control of both tumor and secondary retinal detachment.
Keywords
Adult
Aged
Choroid Neoplasms/etiology/pathology/*radiotherapy
Dose Fractionation
Female
Follow-Up Studies
Hemangioma, Capillary/etiology/pathology/*radiotherapy
Humans
Male
Middle Aged
Optic Nerve/radiation effects
Optic Nerve Diseases/etiology
*Protons/adverse effects
Radiation Injuries/etiology
Radiotherapy Dosage
Retinal Detachment/etiology/physiopathology
Sturge-Weber Syndrome/complications
Visual Acuity
Pubmed
Web of science
Create date
28/01/2008 14:09
Last modification date
20/08/2019 17:17