Lactate modulation of immune responses in inflammatory versus tumour microenvironments.

Détails

ID Serval
serval:BIB_EEC32C274BAF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Lactate modulation of immune responses in inflammatory versus tumour microenvironments.
Périodique
Nature reviews. Immunology
Auteur(s)
Certo M., Tsai C.H., Pucino V., Ho P.C., Mauro C.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
03/2021
Peer-reviewed
Oui
Volume
21
Numéro
3
Pages
151-161
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-inflammatory and anti-resolution. Despite these opposing immunological states, the metabolic states in the tissue microenvironments of cancer and inflammatory diseases are similar: both are hypoxic, show elevated levels of lactate and other metabolic by-products and have low levels of nutrients. In this Review, we describe how the bioavailability of lactate differs in the microenvironments of tumours and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease. A clear understanding of the metabolic signature of tumours and inflammatory diseases will enable therapeutic intervention aimed at resetting the bioavailability of metabolites and correcting the dysregulated immunological state, triggering beneficial cytotoxic, inflammatory responses in tumours and immunosuppressive responses in chronic inflammation.
Mots-clé
Biological Availability, Carrier Proteins/metabolism, Humans, Inflammation/immunology, L-Lactate Dehydrogenase/metabolism, Lactic Acid/metabolism, Membrane Proteins/metabolism, Neoplasms/immunology, Neoplasms/pathology, Thyroid Hormones/metabolism, Tumor Microenvironment/immunology
Pubmed
Web of science
Création de la notice
02/09/2020 11:16
Dernière modification de la notice
08/05/2021 6:32
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