Lactate modulation of immune responses in inflammatory versus tumour microenvironments.
Details
Serval ID
serval:BIB_EEC32C274BAF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lactate modulation of immune responses in inflammatory versus tumour microenvironments.
Journal
Nature reviews. Immunology
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Publication state
Published
Issued date
03/2021
Peer-reviewed
Oui
Volume
21
Number
3
Pages
151-161
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
The microenvironment in cancerous tissues is immunosuppressive and pro-tumorigenic, whereas the microenvironment of tissues affected by chronic inflammatory disease is pro-inflammatory and anti-resolution. Despite these opposing immunological states, the metabolic states in the tissue microenvironments of cancer and inflammatory diseases are similar: both are hypoxic, show elevated levels of lactate and other metabolic by-products and have low levels of nutrients. In this Review, we describe how the bioavailability of lactate differs in the microenvironments of tumours and inflammatory diseases compared with normal tissues, thus contributing to the establishment of specific immunological states in disease. A clear understanding of the metabolic signature of tumours and inflammatory diseases will enable therapeutic intervention aimed at resetting the bioavailability of metabolites and correcting the dysregulated immunological state, triggering beneficial cytotoxic, inflammatory responses in tumours and immunosuppressive responses in chronic inflammation.
Keywords
Biological Availability, Carrier Proteins/metabolism, Humans, Inflammation/immunology, L-Lactate Dehydrogenase/metabolism, Lactic Acid/metabolism, Membrane Proteins/metabolism, Neoplasms/immunology, Neoplasms/pathology, Thyroid Hormones/metabolism, Tumor Microenvironment/immunology
Pubmed
Web of science
Create date
02/09/2020 11:16
Last modification date
08/05/2021 6:32